Gene/Proteome Database (LMPD)

LMPD ID
LMP013646
Gene ID
100145871
Species
Rattus norvegicus (Rat)
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
Adh5
Alternate Names
alcohol dehydrogenase class-3; FDH; FALDH; ADH-B2; GSH-FDH; alcohol dehydrogenase 2; alcohol dehydrogenase B2; alcohol dehydrogenase class-III; S-(hydroxymethyl)glutathione dehydrogenase; class III alcohol dehydrogenase, chi subunit; glutathione-dependent formaldehyde dehydrogenase;
Chromosome
2
Map Location
2q44
EC Number
1.1.1.1

Proteins

alcohol dehydrogenase class-3
Refseq ID NP_001119592
Protein GI 186972146
UniProt ID P12711
mRNA ID NM_001126120
Length 374
MANQVIRCKAAVAWEAGKPLSIEEIEVAPPQAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKPILHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGATECINPQDFSKSIQEVLIEMTDGGVDFSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINKAFDLMHSGNSIRTVLKM

Gene Information

Entrez Gene ID
100145871
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
Adh5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005634 IDA:RGD C nucleus
GO:0004022 IDA:RGD F alcohol dehydrogenase (NAD) activity
GO:0005504 IEA:Ensembl F fatty acid binding
GO:0018467 IEA:Ensembl F formaldehyde dehydrogenase activity
GO:0051903 IEA:UniProtKB-EC F S-(hydroxymethyl)glutathione dehydrogenase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0007568 IEP:RGD P aging
GO:0006068 IDA:RGD P ethanol catabolic process
GO:0006069 IEA:InterPro P ethanol oxidation
GO:0046294 IEA:Ensembl P formaldehyde catabolic process
GO:0018119 IEA:Ensembl P peptidyl-cysteine S-nitrosylation
GO:0045777 IEA:Ensembl P positive regulation of blood pressure
GO:0003016 IEA:Ensembl P respiratory system process
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0051409 IEA:Ensembl P response to nitrosative stress
GO:0051775 IEA:Ensembl P response to redox state
GO:0001523 IEA:Ensembl P retinoid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko01200 Carbon metabolism
rno01200 Carbon metabolism
ko05204 Chemical carcinogenesis
rno05204 Chemical carcinogenesis
ko01220 Degradation of aromatic compounds
rno01220 Degradation of aromatic compounds
ko00982 Drug metabolism - cytochrome P450
rno00982 Drug metabolism - cytochrome P450
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
rno01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
rno00980 Metabolism of xenobiotics by cytochrome P450
ko00830 Retinol metabolism
rno00830 Retinol metabolism
ko00350 Tyrosine metabolism
rno00350 Tyrosine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR014183 Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Protein Entry
ADHX_RAT
UniProt ID
P12711
Species
Rat

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Catalytic Activity S-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 2 Zn(2+) ions per subunit. ;
Function Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
Sequence Caution Sequence=AAH83724.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily
Subcellular Location Cytoplasm.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP013646 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
186972146 RefSeq NP_001119592 374 alcohol dehydrogenase class-3

Identical Sequences to LMP013646 proteins

Reference Database Accession Length Protein Name
GI:186972146 GenBank EDL82320.1 374 rCG28558 [Rattus norvegicus]
GI:186972146 SwissProt P12711.2 374 RecName: Full=Alcohol dehydrogenase class-3; AltName: Full=Alcohol dehydrogenase 2; AltName: Full=Alcohol dehydrogenase 5; AltName: Full=Alcohol dehydrogenase B2; Short=ADH-B2; AltName: Full=Alcohol dehydrogenase class-III; AltName: Full=Glutathione-dependent formaldehyde dehydrogenase; Short=FALDH; Short=FDH; Short=GSH-FDH; AltName: Full=S-(hydroxymethyl)glutathione dehydrogenase [Rattus norvegicus]

Related Sequences to LMP013646 proteins

Reference Database Accession Length Protein Name
GI:186972146 GenBank AAH83724.1 379 Adh5 protein, partial [Rattus norvegicus]
GI:186972146 GenBank AAH90978.1 374 Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus]
GI:186972146 GenBank EDL82320.1 374 rCG28558 [Rattus norvegicus]
GI:186972146 SwissProt P12711.2 374 RecName: Full=Alcohol dehydrogenase class-3; AltName: Full=Alcohol dehydrogenase 2; AltName: Full=Alcohol dehydrogenase 5; AltName: Full=Alcohol dehydrogenase B2; Short=ADH-B2; AltName: Full=Alcohol dehydrogenase class-III; AltName: Full=Glutathione-dependent formaldehyde dehydrogenase; Short=FALDH; Short=FDH; Short=GSH-FDH; AltName: Full=S-(hydroxymethyl)glutathione dehydrogenase [Rattus norvegicus]