Gene/Proteome Database (LMPD)

LMPD ID
LMP013981
Gene ID
678688
Species
Macaca mulatta (Rhesus monkey)
Gene Name
cytochrome P450, family 2, subfamily E, polypeptide 1
Gene Symbol
CYP2E1
Alternate Names
cytochrome P450 2E1; CYPIIE1; cytochrome P450 CYP2E1; 4-nitrophenol 2-hydroxylase;
Chromosome
9
Map Location
chromosome:9
EC Number
1.14.13.-

Proteins

cytochrome P450 2E1 precursor
Refseq ID NP_001035303
Protein GI 94158996
UniProt ID Q6GUQ4
mRNA ID NM_001040213
Length 493
MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGDIPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFQLLSTPWLQLYNNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYIIPKGTVIVPTLDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLLLSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPRS
sig_peptide: 1..28 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3048 peptide sequence: MSALGVSVALLVWVAVLLLVSIWRQVHS

Gene Information

Entrez Gene ID
678688
Gene Name
cytochrome P450, family 2, subfamily E, polypeptide 1
Gene Symbol
CYP2E1
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016709 IEA:UniProtKB-EC F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
mcc00590 Arachidonic acid metabolism
ko05204 Chemical carcinogenesis
mcc05204 Chemical carcinogenesis
ko00982 Drug metabolism - cytochrome P450
mcc00982 Drug metabolism - cytochrome P450
ko00591 Linoleic acid metabolism
mcc00591 Linoleic acid metabolism
mcc01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
mcc00980 Metabolism of xenobiotics by cytochrome P450
ko04932 Non-alcoholic fatty liver disease (NAFLD)
mcc04932 Non-alcoholic fatty liver disease (NAFLD)
ko00140 Steroid hormone biosynthesis
mcc00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR008070 Cytochrome P450, E-class, group I, CYP2E-like
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 2, subfamily E, polypeptide 1
Protein Entry
CP2E1_MACMU
UniProt ID
Q6GUQ4
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Function Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.
Induction By ethanol.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP013981 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
94158996 RefSeq NP_001035303 493 cytochrome P450 2E1 precursor

Identical Sequences to LMP013981 proteins

Reference Database Accession Length Protein Name
GI:94158996 GenBank AAT49269.1 493 cytochrome P450 CYP2E1 [Macaca mulatta]
GI:94158996 SwissProt Q6GUQ4.1 493 RecName: Full=Cytochrome P450 2E1; AltName: Full=4-nitrophenol 2-hydroxylase; AltName: Full=CYPIIE1 [Macaca mulatta]

Related Sequences to LMP013981 proteins

Reference Database Accession Length Protein Name
GI:94158996 RefSeq XP_008015474.1 559 PREDICTED: cytochrome P450 2E1 [Chlorocebus sabaeus]
GI:94158996 RefSeq XP_010385239.1 493 PREDICTED: cytochrome P450 2E1 [Rhinopithecus roxellana]