Gene/Proteome Database (LMPD)

LMPD ID
LMP014471
Gene ID
574255
Species
Macaca mulatta (Rhesus monkey)
Gene Name
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Gene Symbol
PAFAH1B1
Synonyms
LIS1;
Alternate Names
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase IB subunit alpha; platelet activating factor acetylhydrolase 45 kDa subunit brain isoform;
Chromosome
16
Map Location
chromosome:16

Proteins

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Refseq ID NP_001245059
Protein GI 384475827
UniProt ID F7AE78
mRNA ID NM_001258130
Length 410
Protein sequence is identical to GI:109112726 (mRNA isoform)
Refseq ID XP_001087675
Protein GI 109112726
UniProt ID F7AE78
mRNA ID XM_001087675
Length 410
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLTSCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHLVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR

Gene Information

Entrez Gene ID
574255
Gene Name
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Gene Symbol
PAFAH1B1
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000235 IEA:Ensembl C astral microtubule
GO:0005938 IEA:Ensembl C cell cortex
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0000776 IEA:Ensembl C kinetochore
GO:0005875 IEA:UniProtKB-HAMAP C microtubule associated complex
GO:0005815 IEA:UniProtKB-SubCell C microtubule organizing center
GO:0031965 IEA:UniProtKB-SubCell C nuclear membrane
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0008344 IEA:Ensembl P adult locomotory behavior
GO:0048854 IEA:Ensembl P brain morphogenesis
GO:0006928 IEA:UniProtKB-HAMAP P cellular component movement
GO:0021987 IEA:Ensembl P cerebral cortex development
GO:0021540 IEA:Ensembl P corpus callosum morphogenesis
GO:0000132 IEA:UniProtKB-HAMAP P establishment of mitotic spindle orientation
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0031023 IEA:Ensembl P microtubule organizing center organization
GO:0007067 IEA:UniProtKB-KW P mitotic nuclear division
GO:0050885 IEA:Ensembl P neuromuscular process controlling balance
GO:0006810 IEA:UniProtKB-KW P transport

KEGG Pathway Links

KEGG Pathway ID Description
ko00565 Ether lipid metabolism
mcc00565 Ether lipid metabolism
mcc01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR017252 Dynein_regulator_LIS1
IPR020472 G-protein beta WD-40 repeat
IPR006594 LisH dimerisation motif
IPR013720 LisH dimerisation motif, subgroup
IPR019775 WD40 repeat, conserved site
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Protein Entry
F7AE78_MACMU
UniProt ID
F7AE78
Species
Rhesus monkey

Comments

Comment Type Description
Domain Dimerization mediated by the LisH domain may be required to activate dynein.
Function Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein- mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
Similarity Belongs to the WD repeat LIS1/nudF family.
Similarity Contains 1 LisH domain. {ECO:0000256|HAMAP- Rule:MF_03141}.
Similarity Contains 7 WD repeats. {ECO:0000256|HAMAP- Rule:MF_03141}.
Similarity Contains LisH domain.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000256|HAMAP- Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Nucleus membrane Note=Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes.
Subunit Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.

Identical and Related Proteins

Unique RefSeq proteins for LMP014471 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109112726 RefSeq XP_001087675 410 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)

Identical Sequences to LMP014471 proteins

Reference Database Accession Length Protein Name
GI:384475827 RefSeq XP_003912131.1 410 PREDICTED: platelet-activating factor acetylhydrolase IB subunit alpha [Papio anubis]
GI:384475827 RefSeq XP_005582540.1 410 PREDICTED: uncharacterized LOC101866353 isoform X1 [Macaca fascicularis]
GI:384475827 RefSeq XP_005582541.1 410 PREDICTED: uncharacterized LOC101866353 isoform X2 [Macaca fascicularis]
GI:384475827 RefSeq XP_010386787.1 410 PREDICTED: platelet-activating factor acetylhydrolase IB subunit alpha [Rhinopithecus roxellana]

Related Sequences to LMP014471 proteins

Reference Database Accession Length Protein Name
GI:384475827 GenBank AFH27829.1 410 platelet-activating factor acetylhydrolase IB subunit alpha [Macaca mulatta]