Gene/Proteome Database (LMPD)

LMPD ID
LMP014722
Gene ID
705121
Species
Macaca mulatta (Rhesus monkey)
Gene Name
phosphatase and tensin homolog
Gene Symbol
PTEN
Alternate Names
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;
Chromosome
9
Map Location
chromosome:9

Proteins

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Refseq ID NP_001247894
Protein GI 386781546
UniProt ID F6VBA7
mRNA ID NM_001260965
Length 403
Protein sequence is identical to GI:109089825 (mRNA isoform)
Refseq ID XP_001102542
Protein GI 109089825
UniProt ID F6VBA7
mRNA ID XM_001102542
Length 403
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV

Gene Information

Entrez Gene ID
705121
Gene Name
phosphatase and tensin homolog
Gene Symbol
PTEN
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0009898 IEA:Ensembl C cytoplasmic side of plasma membrane
GO:0035749 IEA:Ensembl C myelin sheath adaxonal region
GO:0043005 IEA:Ensembl C neuron projection
GO:0005634 IEA:Ensembl C nucleus
GO:0043220 IEA:Ensembl C Schmidt-Lanterman incisure
GO:0051717 IEA:Ensembl F inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0016314 IEA:InterPro F phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800 IEA:InterPro F phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438 IEA:Ensembl F phosphatidylinositol-3-phosphatase activity
GO:0004722 IEA:Ensembl F protein serine/threonine phosphatase activity
GO:0004725 IEA:InterPro F protein tyrosine phosphatase activity
GO:0008138 IEA:InterPro F protein tyrosine/serine/threonine phosphatase activity
GO:0007092 IEA:Ensembl P activation of mitotic anaphase-promoting complex activity
GO:0001525 IEA:Ensembl P angiogenesis
GO:0060070 IEA:Ensembl P canonical Wnt signaling pathway
GO:0048738 IEA:Ensembl P cardiac muscle tissue development
GO:0032286 IEA:Ensembl P central nervous system myelin maintenance
GO:0021955 IEA:Ensembl P central nervous system neuron axonogenesis
GO:0060997 IEA:Ensembl P dendritic spine morphogenesis
GO:0021542 IEA:Ensembl P dentate gyrus development
GO:0043542 IEA:Ensembl P endothelial cell migration
GO:0048853 IEA:Ensembl P forebrain morphogenesis
GO:0046855 IEA:InterPro P inositol phosphate dephosphorylation
GO:0007611 IEA:Ensembl P learning or memory
GO:0045475 IEA:Ensembl P locomotor rhythm
GO:0060291 IEA:Ensembl P long-term synaptic potentiation
GO:0060179 IEA:Ensembl P male mating behavior
GO:0042711 IEA:Ensembl P maternal behavior
GO:0033555 IEA:Ensembl P multicellular organismal response to stress
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0050771 IEA:Ensembl P negative regulation of axonogenesis
GO:0090344 IEA:Ensembl P negative regulation of cell aging
GO:0030336 IEA:InterPro P negative regulation of cell migration
GO:0045792 IEA:Ensembl P negative regulation of cell size
GO:0031658 IEA:Ensembl P negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0061002 IEA:Ensembl P negative regulation of dendritic spine morphogenesis
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0090394 IEA:Ensembl P negative regulation of excitatory postsynaptic membrane potential
GO:0051895 IEA:InterPro P negative regulation of focal adhesion assembly
GO:2000134 IEA:Ensembl P negative regulation of G1/S transition of mitotic cell cycle
GO:0031642 IEA:Ensembl P negative regulation of myelination
GO:0046621 IEA:Ensembl P negative regulation of organ growth
GO:0051898 IEA:Ensembl P negative regulation of protein kinase B signaling
GO:0090071 IEA:Ensembl P negative regulation of ribosome biogenesis
GO:2000808 IEA:Ensembl P negative regulation of synaptic vesicle clustering
GO:0007270 IEA:Ensembl P neuron-neuron synaptic transmission
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation
GO:2001235 IEA:Ensembl P positive regulation of apoptotic signaling pathway
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:2000463 IEA:Ensembl P positive regulation of excitatory postsynaptic membrane potential
GO:2000060 IEA:Ensembl P positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091 IEA:Ensembl P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107 IEA:Ensembl P postsynaptic density assembly
GO:0060134 IEA:Ensembl P prepulse inhibition
GO:0097105 IEA:Ensembl P presynaptic membrane assembly
GO:0060736 IEA:Ensembl P prostate gland growth
GO:0043491 IEA:Ensembl P protein kinase B signaling
GO:0050821 IEA:Ensembl P protein stabilization
GO:0002902 IEA:Ensembl P regulation of B cell apoptotic process
GO:0033032 IEA:Ensembl P regulation of myeloid cell apoptotic process
GO:0060024 IEA:Ensembl P rhythmic synaptic transmission
GO:0035176 IEA:Ensembl P social behavior
GO:0060074 IEA:Ensembl P synapse maturation

KEGG Pathway Links

KEGG Pathway ID Description
ko05213 Endometrial cancer
mcc05213 Endometrial cancer
ko04510 Focal adhesion
mcc04510 Focal adhesion
mcc04068 FoxO signaling pathway
ko05214 Glioma
mcc05214 Glioma
mcc05161 Hepatitis B
ko00562 Inositol phosphate metabolism
mcc00562 Inositol phosphate metabolism
ko05218 Melanoma
mcc05218 Melanoma
ko05206 MicroRNAs in cancer
mcc05206 MicroRNAs in cancer
ko04150 mTOR signaling pathway
mcc04150 mTOR signaling pathway
ko04115 p53 signaling pathway
mcc04115 p53 signaling pathway
mcc05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
mcc04070 Phosphatidylinositol signaling system
ko04151 PI3K-Akt signaling pathway
mcc04151 PI3K-Akt signaling pathway
ko05215 Prostate cancer
mcc05215 Prostate cancer
ko05222 Small cell lung cancer
mcc05222 Small cell lung cancer
ko04530 Tight junction
mcc04530 Tight junction

Domain Information

InterPro Annotations

Accession Description
IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
IPR000008 C2 domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR016130 Protein-tyrosine phosphatase, active site
IPR029021 Protein-tyrosine phosphatase-like
IPR014020 Tensin phosphatase, C2 domain
IPR029023 Tensin phosphatase, lipid phosphatase domain

UniProt Annotations

Entry Information

Gene Name
phosphatase and tensin homolog
Protein Entry
F6VBA7_MACMU
UniProt ID
F6VBA7
Species
Rhesus monkey

Identical and Related Proteins

Unique RefSeq proteins for LMP014722 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109089825 RefSeq XP_001102542 403 phosphatase and tensin homolog

Identical Sequences to LMP014722 proteins

Reference Database Accession Length Protein Name
GI:386781546 RefSeq XP_008534287.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [Equus przewalskii]
GI:386781546 RefSeq XP_008574034.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Galeopterus variegatus]
GI:386781546 RefSeq XP_008687806.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Ursus maritimus]
GI:386781546 RefSeq XP_010377926.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Rhinopithecus roxellana]

Related Sequences to LMP014722 proteins

Reference Database Accession Length Protein Name
GI:386781546 GenBank AAC51182.1 403 MMAC1 [Homo sapiens]
GI:386781546 GenBank AAC51183.1 403 putative protein tyrosine phosphatase [Homo sapiens]
GI:386781546 GenBank AAB66902.1 403 protein tyrosine phosphatase [Homo sapiens]
GI:386781546 GenBank AAC08699.1 403 putative protein tyrosine phosphatase [Homo sapiens]