Gene/Proteome Database (LMPD)

LMPD ID
LMP014967
Gene ID
574360
Species
Macaca mulatta (Rhesus monkey)
Gene Name
toll-like receptor 4
Gene Symbol
TLR4
Synonyms
hToll;
Alternate Names
toll-like receptor 4;
Chromosome
15
Map Location
chromosome:15

Proteins

toll-like receptor 4 precursor
Refseq ID NP_001032169
Protein GI 198282105
UniProt ID B3Y632
mRNA ID NM_001037092
Length 826
MTSALRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELKFYKIPDNIPFSTKNLDLSFNPLRHLGSYSFLRFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQNIYCKDLQVLHQMPLSNLSLDLSLNPINFIQPGAFKEIRLHKLTLRSNFDDLNVMKTCIQGLAGLEVHRLVLGEFRNERNLEEFDKSSLEGLCNLTIEEFRLTYLDYYLDNIIDLFNCLANVSSFSLVSVSIKRVEDFSYNFRWQHLELVNCKFEQFPTLELESLKRLTFTANKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNDVITMSSNFLGLEKLEHLDFQHSNLKQMSQFSVFLSLRNLIYLDISHTHTRVAFNGIFDGLLSLKVLKMAGNSFQENFLPDIFTDLKNLTFLDLSQCQLEQLSPTAFDTLNKLQVLNMSHNNFFSLDTFPYKCLPSLQVLDYSLNHIMTSNNQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEAERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVFSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGQHIFWRRLRKALLDGRSWNPEEQ
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2420 peptide sequence: MTSALRLAGTLIPAMAFLSCVRP

Gene Information

Entrez Gene ID
574360
Gene Name
toll-like receptor 4
Gene Symbol
TLR4
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0046696 IEA:InterPro C lipopolysaccharide receptor complex
GO:0001875 IEA:InterPro F lipopolysaccharide receptor activity
GO:0004888 IEA:InterPro F transmembrane signaling receptor activity
GO:0002755 IEA:InterPro P MyD88-dependent toll-like receptor signaling pathway
GO:0050829 IEA:InterPro P defense response to Gram-negative bacterium
GO:0006954 IEA:UniProtKB-KW P inflammatory response
GO:0045087 IEA:UniProtKB-KW P innate immune response
GO:0042116 IEA:InterPro P macrophage activation
GO:0050707 IEA:InterPro P regulation of cytokine secretion
GO:0034142 IEA:InterPro P toll-like receptor 4 signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko05146 Amoebiasis
mcc05146 Amoebiasis
ko05142 Chagas disease (American trypanosomiasis)
mcc05142 Chagas disease (American trypanosomiasis)
mcc04066 HIF-1 signaling pathway
mcc05161 Hepatitis B
ko05321 Inflammatory bowel disease (IBD)
mcc05321 Inflammatory bowel disease (IBD)
ko05164 Influenza A
mcc05164 Influenza A
ko05134 Legionellosis
mcc05134 Legionellosis
ko05140 Leishmaniasis
mcc05140 Leishmaniasis
ko05144 Malaria
mcc05144 Malaria
ko05162 Measles
mcc05162 Measles
mcc04064 NF-kappa B signaling pathway
ko04151 PI3K-Akt signaling pathway
mcc04151 PI3K-Akt signaling pathway
ko05133 Pertussis
mcc05133 Pertussis
ko04145 Phagosome
mcc04145 Phagosome
ko05205 Proteoglycans in cancer
mcc05205 Proteoglycans in cancer
ko05323 Rheumatoid arthritis
mcc05323 Rheumatoid arthritis
ko05132 Salmonella infection
mcc05132 Salmonella infection
ko04620 Toll-like receptor signaling pathway
mcc04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
mcc05145 Toxoplasmosis
ko05152 Tuberculosis
mcc05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR000483 Cysteine-rich flanking region, C-terminal
IPR025875 Leucine rich repeat 4
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR017241 Toll-like receptor
IPR027168 Toll-like receptor 4
IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

UniProt Annotations

Entry Information

Gene Name
toll-like receptor 4
Protein Entry
B3Y632_MACMU
UniProt ID
B3Y632
Species
Rhesus monkey

Comments

Comment Type Description
Similarity Belongs to the Toll-like receptor family.
Similarity Contains TIR domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP014967 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
198282105 RefSeq NP_001032169 826 toll-like receptor 4 precursor

Identical Sequences to LMP014967 proteins

Reference Database Accession Length Protein Name
GI:198282105 DBBJ BAG55041.1 826 toll-like receptor 4 [Macaca mulatta]
GI:198282105 GenBank EHH23828.1 826 hToll [Macaca mulatta]

Related Sequences to LMP014967 proteins

Reference Database Accession Length Protein Name
GI:198282105 DBBJ BAG55040.1 826 toll-like receptor 4 [Macaca fascicularis]
GI:198282105 RefSeq XP_005580995.1 843 PREDICTED: LOW QUALITY PROTEIN: toll-like receptor 4 [Macaca fascicularis]