Genkwanin is a flavonoid that has been found in T. kirilowii and has diverse biological activities.^1,2 It inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer, Eca-109 esophageal carcinoma, and A549 lung adenocarcinoma cells (IC50s = 58.54, 101.4, 98.2, and 120.77 µM, respectively).¹ It decreases the levels of PI3Kγ, as well as the levels of phosphorylated Akt, mTOR, p70 ribosomal S6 kinase (p70S6K) and ULK, and induces apoptosis and cell cycle arrest at the G2/M phase in MDA-MB-231 cells. Genkwanin (20-40 µM) reverses increases in apoptosis, lactate dehydrogenase (LDH) release, and reactive oxygen species (ROS) production induced by 1-methyl-4-phenylpyridinium (MPP+) in an in vitro model of Parkinson’s disease inflammation using SH-SY5Y cells.² It also reduces protein levels of toll-like receptor 4 (TLR4), MyD88, NOD-like receptor protein 3 (NLRP3), and caspase-1 in SH-SY5Y cells.