LIPID MAPS

Structure Database (LMSD)

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Common Name

Broussochalcone B

Systematic Name

Synonyms

LM ID

LMPK12120045

Formula

C₂₀H₂₀O₄

Exact Mass

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324.13616

Status

Curated

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Classification

Biological Context

Bavachalcone is a polyketide synthase-derived chalcone and flavonoid that has been found in P. corylifolia and has diverse biological activities.^1,2,3,4,5 It inhibits α-glucosidase and the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT1A7 (IC50s = 11.1, 11.3, and 3.6 µM, respectively).^2,3 Bavachalcone is cytotoxic to K562 chronic myeloid leukemia cells (IC50 = 2.77 µM).⁴ It inhibits RANKL-induced osteoclastogenesis of isolated mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 µg/ml.⁵

This information has been provided by Cayman Chemical

References

1. Park, C.K., Lee, Y., Chang, E.-J., et al. Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem. Pharmacol. 75(11), 2175-2182 (2008).

2. Wang, H.-M., Zhang, L., Liu, J., et al. Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs. Eur. J. Med. Chem. 92, 439-448 (2015).

3. Shan, L., Yang, S., Zhang, G., et al. Comparison of the inhibitory potential of bavachalcone and corylin against UDP-glucuronosyltransferases. Evid. Based Complement. Alternat. Med. 958937 (2014).

4. Ryu, H.W., Lee, B.W., Curtis-Long, M.J., et al. Polyphenols from Broussonetia papyrifera displaying potent α-glucosidase inhibition. J. Agric. Food Chem. 58(1), 202-208 (2010).

5. Zhou, K., Yang, S., and Li, S.-M. Naturally occurring prenylated chalcones from plants: Structural diversity, distribution, activities and biosynthesis. Nat. Prod. Rep. (2021).