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Hydrocortisone acetate is a synthetic corticosteroid.^1,2 Topical administration of hydrocortisone acetate (0.1% v/v) reduces corneal haze and hydroxyproline levels without reducing the stromal wound healing response in a rabbit model of photorefractive keratectomy.¹ Hydrocortisone acetate enhances and reduces cartilage degradation in a mouse model of air pouch cartilage implantation when injected into the air pouch cavity or into the air pouch lining tissue, respectively.² Formulations containing hydrocortisone acetate have been used in the treatment of joint inflammation and rheumatoid arthritis.

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References

1. Bilgihan, K., Ozdek, S., Ozoğul, C., et al. Topical vitamin E and hydrocortisone acetate treatment after photorefractive keratectomy. Eye (Lond) 14(Pt 2), 231-237 (2000).

2. Sedgwick, A.D., Sin, Y.M., Moore, A.R., et al. Effects of local administration of hydrocortisone on cartilage degradation in vivo. Ann. Rheum. Dis. 43(3), 418-420 (1984).

String Representations

InChiKey (Click to copy)

ALEXXDVDDISNDU-JZYPGELDSA-N

InChi (Click to copy)

InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

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