5,7,3',4'-Tetramethoxyflavone is a flavone that has been found in M. paniculata and has diverse biological activities.^1,2,3,4,5,6 It selectively inhibits multidrug resistance-associated protein 1 (MRP1) over MRP2 (IC50s = 7.9 and >50 µM, respectively).¹ 5,7,3',4'-Tetramethoxyflavone (0.03-30 µM) inhibits LPS-induced nitric oxide (NO) release in primary mouse peritoneal macrophages.² It is active against P. falciparum (IC50 = 4.06 µg/ml).³ 5,7,3',4'-Tetramethoxyflavone (20 µM) is cytotoxic to B16/F10 melanoma cells.⁴ It inhibits IL-33-induced production of chemokine (C-C motif) ligand 2 (CCL2) and CCL5 in primary human mast cells when used at concentrations of 50 and 100 µM.⁵ In vivo, 5,7,3',4'-tetramethoxyflavone (100 mg/kg) decreases the synovial fluid levels of prostaglandin E2 (PGE2), IL-1β, and TNF-α in a rat model of surgically induced osteoarthritis.⁶