LMPD Database

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LMP001699

UniProt Annotations

Entry Information
Gene Namealkaline ceramidase 3
Protein EntryACER3_HUMAN
UniProt IDQ9NUN7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NUN7-1; Sequence=Displayed; Name=2; IsoId=Q9NUN7-2; Sequence=VSP_039162, VSP_039163; Note=No experimental confirmation available.;
Enzyme RegulationActivated by Ca(2+) and inhibited by Zn(2+).
FunctionHydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.
SimilarityBelongs to the alkaline ceramidase family.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Tissue SpecificityUbiquitously expressed. Highest expression in placenta.