LMPD Database

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LMP002047

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 1 family, member A3
Protein EntryH0Y2X5_HUMAN
UniProt IDQ7Z3A2
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAn aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
DiseaseMicrophthalmia, isolated, 8 (MCOP8) [MIM
FunctionRecognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
PathwayCofactor metabolism; retinol metabolism.
SimilarityBelongs to the aldehyde dehydrogenase family.
Subcellular LocationCytoplasm .
Tissue SpecificityExpressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.