LMPD Database

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LMP002220

UniProt Annotations

Entry Information
Gene Namedegenerative spermatocyte homolog 2 (Drosophila), lipid desaturase
Protein EntryQ8R2F2_MOUSE
UniProt IDQ8R2F2
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q8R2F2-1; Sequence=Displayed; Name=2 ; IsoId=Q8R2F2-2; Sequence=VSP_052629; Note=No experimental confirmation available. ;
Biophysicochemical PropertiespH dependence: Optimum pH is 7.0-8.0. ;
FunctionBifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. {ECO:0000269|PubMed:11937514, ECO:0000269|PubMed:14731113, ECO:0000269|PubMed:16571104}.
PathwayMembrane lipid metabolism; sphingolipid biosynthesis.
SimilarityBelongs to the fatty acid desaturase family. DEGS subfamily.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityHighly expressed in intestinal crypt cells and adjacent epithelial cells (at protein level).