LMPD Database

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LMP004813

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 16
Protein EntryCXL16_HUMAN
UniProt IDQ9H2A7
SpeciesHuman
Comments
Comment typeDescription
FunctionActs as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
PtmGlycosylated.
Sequence CautionSequence=AAG34365.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH17588.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH44930.1; Type=Erroneous initiation; Evidence= ; Sequence=ABK41925.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB55078.1; Type=Erroneous initiation; Evidence= ; Sequence=BAF84803.1; Type=Erroneous initiation; Evidence= ; Sequence=BAG37507.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the intercrine alpha (chemokine CxC) family.
Subcellular LocationCell membrane ; Single-pass type I membrane protein . Secreted. Note=Also exists as a soluble form.
Tissue SpecificityExpressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Web ResourceName=Wikipedia; Note=CXCL16 entry; URL="http://en.wikipedia.org/wiki/CXCL16";