LMPD Database

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LMP006717

UniProt Annotations

Entry Information
Gene Nameapolipoprotein O
Protein EntryAPOO_HUMAN
UniProt IDQ9BUR5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BUR5-1; Sequence=Displayed; Name=2; IsoId=Q9BUR5-2; Sequence=VSP_023333;
FunctionPromotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.
PtmO-glycosylation; glycosaminoglycan of chondroitin-sulfate type.
SimilarityBelongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
Subcellular LocationMembrane ; Single-pass membrane protein {ECO
Tissue SpecificityExpressed in all tissues examined. Up- regulated in diabetic heart.