LMPD Database

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LMP007065

UniProt Annotations

Entry Information
Gene Nameputative lipoate--protein ligase
Protein EntryLPLA_YEAST
UniProt IDP47051
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + lipoate = diphosphate + lipoyl-AMP.
Catalytic ActivityLipoyl-AMP + protein = protein N(6)- (lipoyl)lysine + AMP.
FunctionCatalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
FunctionCatalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. {ECO:0000250}.
MiscellaneousIn the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon- amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes
MiscellaneousIn the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon- amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. {ECO:0000250}.
PathwayProtein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.
PathwayProtein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.
Sequence CautionSequence=AAS56406.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA89337.1; Type=Erroneous initiation; Evidence= ;
Sequence CautionSequence=AAS56406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA89337.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the LplA family
SimilarityBelongs to the LplA family. {ECO:0000305}.
SimilarityContains 1 BPL/LPL catalytic domain
SimilarityContains 1 BPL/LPL catalytic domain. {ECO:0000255|PROSITE-ProRule:PRU01067}.
SubunitMonomer
SubunitMonomer. {ECO:0000250}.