LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007115

UniProt Annotations

Entry Information
Gene Namesuccinate dehydrogenase flavoprotein subunit SDH1
Protein EntrySDHA_YEAST
UniProt IDQ00711
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivitySuccinate + a quinone = fumarate + a quinol.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
FunctionCatalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4.
MiscellaneousPresent with 10400 molecules/cell in log phase SD medium
MiscellaneousPresent with 10400 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayCarbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
SimilarityBelongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
SimilarityBelongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane {ECO:0000269|PubMed:11502169}; Peripheral membrane protein {ECO:0000269|PubMed:11502169}; Matrix side {ECO:0000269|PubMed:11502169}.
Subcellular LocationMitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
SubunitComponent of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. Interacts with EMI5/SDH5; interaction is required for FAD attachment
SubunitComponent of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. Interacts with EMI5/SDH5; interaction is required for FAD attachment. {ECO:0000269|PubMed:19628817}.