LMPD Database

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LMP007302

UniProt Annotations

Entry Information
Gene NameAkr1p
Protein EntryAKR1_YEAST
UniProt IDP39010
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoyltransferase specific for casein kinase 1. Palmitoylates isoforms YCK1 and YCK2 at both C-terminal cysteine residues, which is required for their proper plasma membrane localization. Required for constitutive endocytosis of a-factor receptor STE3 and both constitutive and pheromone-induced endocytosis of alpha-factor receptor STE2. {ECO:0000269|PubMed:10866691, ECO:0000269|PubMed:12370247, ECO:0000269|PubMed:15105419, ECO:0000269|PubMed:8524293, ECO:0000269|PubMed:9243510}.
InteractionP18851:STE4; NbExp=3; IntAct=EBI-2421, EBI-7390; P23291:YCK1; NbExp=3; IntAct=EBI-2421, EBI-4718;
MiscellaneousPresent with 4072 molecules/cell in log phase SD medium
MiscellaneousPresent with 4072 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily
SimilarityBelongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. {ECO:0000305}.
SimilarityContains 1 DHHC-type zinc finger
SimilarityContains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
SimilarityContains 6 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationEarly endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.