LMPD Database

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LMP007304

UniProt Annotations

Entry Information
Gene Namealpha-1,2-mannosyltransferase ALG11
Protein EntryALG11_YEAST
UniProt IDP53954
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D- Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc- diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)- D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D- GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}.
FunctionRequired for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP- dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. {ECO:0000269|PubMed:11278778, ECO:0000269|PubMed:16878994, ECO:0000269|PubMed:19929855}.
InteractionP16661:ALG1; NbExp=2; IntAct=EBI-2497, EBI-2206309;
MiscellaneousPresent with 3140 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:11278778}; Single-pass type II membrane protein {ECO:0000269|PubMed:11278778}.
SubunitInteracts with ALG1. {ECO:0000269|PubMed:15044395}.