LMPD Database

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LMP007368

UniProt Annotations

Entry Information
Gene Nameglutamate N-acetyltransferase
Protein EntryARGJ_YEAST
UniProt IDQ04728
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=8.4 mM for glutamate {ECO:0000269|PubMed:17651682}; KM=2.8 mM for N-acetylornithine {ECO:0000269|PubMed:17651682};
Biophysicochemical PropertiesKinetic parameters: KM=8.4 mM for glutamate ; KM=2.8 mM for N-acetylornithine ;
Catalytic ActivityAcetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate
Catalytic ActivityAcetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate. {ECO:0000255|HAMAP-Rule:MF_03124}.
Catalytic ActivityN(2)-acetyl-L-ornithine + L-glutamate = L- ornithine + N-acetyl-L-glutamate. {ECO:0000255|HAMAP- Rule:MF_03124}.
Enzyme RegulationInhibited by ornithine
Enzyme RegulationInhibited by ornithine. {ECO:0000269|PubMed:9428669}.
FunctionCatalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate
FunctionCatalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate. {ECO:0000255|HAMAP-Rule:MF_03124, ECO:0000269|PubMed:9428669}.
PathwayAmino-acid biosynthesis; L-arginine biosynthesis; L- ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)- acetyl-L-ornithine (cyclic): step 1/1. {ECO:0000255|HAMAP- Rule:MF_03124}.
PathwayAmino-acid biosynthesis; L-arginine biosynthesis; N(2)- acetyl-L-ornithine from L-glutamate: step 1/4. {ECO:0000255|HAMAP- Rule:MF_03124}.
PtmThe alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion
PtmThe alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion. {ECO:0000255|HAMAP-Rule:MF_03124, ECO:0000269|PubMed:10753950}.
SimilarityBelongs to the ArgJ family. {ECO:0000255|HAMAP- Rule:MF_03124}.
Subcellular LocationMitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03124, ECO:0000269|PubMed:14576278}.
SubunitHeterodimer of an alpha and a beta chain.