LMPD Database

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LMP007466

UniProt Annotations

Entry Information
Gene NameAsk10p
Protein EntryASK10_YEAST
UniProt IDP48361
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionPositive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8
FunctionPositive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8. {ECO:0000269|PubMed:14555478, ECO:0000269|PubMed:19956799}.
PtmPhosphorylated in response to various stresses. stress- induced phosphorylation is partially dependent on HOG1. {ECO:0000269|PubMed:14555478, ECO:0000269|PubMed:17287358, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198, ECO:0000269|PubMed:19956799}.
SimilarityBelongs to the RGC1 family
SimilarityBelongs to the RGC1 family. {ECO:0000305}.
SimilarityContains 1 PH domain
SimilarityContains 1 PH domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:19956799}. Note=Displays diffuse cytoplasmic localization, but very rapidly aggregates into punctate spots that appear near the cell surface in response to hypo-osmotic shock.
SubunitComponent of the RNA polymerase II holoenzyme. Interacts with RPO21 and SSN8
SubunitComponent of the RNA polymerase II holoenzyme. Interacts with RPO21 and SSN8. {ECO:0000269|PubMed:14555478}.