LMPD Database

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LMP009680

UniProt Annotations

Entry Information
Gene Name2-succinylbenzoate--CoA ligase
Protein EntryMENE_ARATH
UniProt IDQ8VYJ1
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA. {ECO:0000269|PubMed:18208520}.
Disruption PhenotypeLack of phylloquinone and seedling lethal. {ECO:0000269|PubMed:18208520}.
FunctionInvolved in the biosynthesis of phylloquinone (vitamin K1). Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). {ECO:0000269|PubMed:18208520}.
Sequence CautionSequence=AAF19755.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Accumulates in discrete foci within the chloroplast.
Tissue SpecificityHigh expression in young leaves and flowers. Not expressed in roots. {ECO:0000269|PubMed:12805634, ECO:0000269|PubMed:18208520}.