LMPD Database

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LMP009750

UniProt Annotations

Entry Information
Gene NameAcetate/butyrate--CoA ligase AAE7
Protein EntryAEE7_ARATH
UniProt IDQ8VZF1
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:12805634}.
Catalytic ActivityATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. {ECO:0000269|PubMed:12805634}.
Disruption PhenotypeNo visible phenotype under normal growth conditions, but seedlings have a strong decrease in glutamine and are resistant to the toxic acetate analog monofluoroacetic acid. {ECO:0000269|PubMed:14963767, ECO:0000269|PubMed:15533942}.
FunctionPeroxisomal acetate/butyrate--CoA ligase that is probably involved in the activation of exogenous acetate for entry into the glyoxylate cycle. May play a role to prevent carbon loss from peroxisomes during lipid mobilization. In vitro, is active with both acetate and butyrate. {ECO:0000269|PubMed:12805634, ECO:0000269|PubMed:15533942, ECO:0000269|PubMed:20863290, ECO:0000269|PubMed:21557725}.
Sequence CautionSequence=BAA94975.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:15533942}.
Tissue SpecificityExpressed in roots, leaves, stems, flowers and developing seeds. {ECO:0000269|PubMed:12805634, ECO:0000269|PubMed:15533942}.