LMPD Database

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LMP010494

UniProt Annotations

Entry Information
Gene Nameglutamine amidotransferase and cyclase
Protein EntryHIS4_ARATH
UniProt IDQ9SZ30
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5- aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O.
FunctionIGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR.
PathwayAmino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
SimilarityContains 1 glutamine amidotransferase type-1 domain. {ECO:0000305}.
SimilarityIn the C-terminal section; belongs to the HisA/HisF family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast.