LMPD Database

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LMP010841

UniProt Annotations

Entry Information
Gene Nameprotein SUPPRESSOR OF ACTIN 5
Protein EntrySAC5_ARATH
UniProt IDQ8RW97
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity1-phosphatidyl-1D-myo-inositol 3,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
DomainThe phosphatase catalytic core motif (or RXNCXDCLDRTN motif) from the SAC domain is found in metal-independent protein phosphatases and inositol polyphosphate phosphatases. {ECO:0000250}.
FunctionThe PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250}.
Sequence CautionSequence=AAF97309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
Subcellular LocationVacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
SubunitComponent of the PI(3,5)P2 regulatory complex at least composed of ATG18, SAC/FIG4, FAB1 and VAC14. {ECO:0000250}.
Tissue SpecificityUbiquitous with a higher level of expression in young seedlings than in other tissues. {ECO:0000269|PubMed:12805586}.