LMPD Database

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LMP011360

UniProt Annotations

Entry Information
Gene Nametranscription factor AS1
Protein EntryAS1_ARATH
UniProt IDO80931
SpeciesArabidopsis
Comments
Comment typeDescription
Developmental StagePreferential expression in young and immature plant tissues. In embryos, expressed from the late globular stage onwards. After germination, detected in leaf founder cells and on flowering, in primordia of all floral organs.
DomainA C-terminal domain (252-356) is required for dimerization.
FunctionTranscription factor required for normal cell differentiation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV. Interacts directly with ASYMMETRIC LEAVES 2 (LBD6/AS2) to repress the knox homeobox genes BP/KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3/ETT, KAN2 and YAB5. May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis. {ECO:0000269|PubMed:11076771, ECO:0000269|PubMed:11140682, ECO:0000269|PubMed:11882937, ECO:0000269|PubMed:12750468, ECO:0000269|PubMed:16006579, ECO:0000269|PubMed:16699177, ECO:0000269|PubMed:17395603, ECO:0000269|PubMed:17559509}.
InductionExpression of AS1 in stem cells of the shoot apical meristem is prevented by SHOOT MERISTEMLESS (STM). Expression is activated by GTE6 during leaf morphogenesis. {ECO:0000269|PubMed:16166385}.
InteractionQ8RY59:RCD1; NbExp=2; IntAct=EBI-763232, EBI-2118043;
SimilarityContains 2 HTH myb-type DNA-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00625}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00625}.
SubunitHomodimer. Interacts with LBD6/AS2, HIRA, a probable histone chaperone, and RIK, a predicted RNA binding protein. {ECO:0000269|PubMed:12750468, ECO:0000269|PubMed:12874130, ECO:0000269|PubMed:16243907}.
Tissue SpecificityExpressed in roots, stems, leaves, flowers, siliques and in lateral organ promordia. Found in the inner domain between the adaxial and abaxial domains of leaves. {ECO:0000269|PubMed:17559509}.