LMPD Database

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LMP012906

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-V
Protein EntryAPOA5_RAT
UniProt IDQ9QUH3
SpeciesRat
Comments
Comment typeDescription
FunctionMinor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity)
InductionInduced in early phase of liver regeneration. Expression is maximally increased 6 hours after partial hepatectomy, both at the liver RNA level and at the plasma protein level
PtmPhosphorylation sites are present in the extracellular medium
SimilarityBelongs to the apolipoprotein A1/A4/E family
Subcellular LocationSecreted.
SubunitInteracts with GPIHBP1
Tissue SpecificityLiver